Spatially-distinct programming of macrophage diversity within the granulomas of Mycobacterium tuberculosis infected nonhuman primates
Davide Pisu, Persis S Sunny, Molly L. Nelson, Beth A. Fallert Junecko, Roopa Venugopalan, Mark Rodgers, Henry Jacob Borish, Pauline A Maiello, Charles A. Scanga, Philana Ling Lin, JoAnne L. Flynn, David G. Russell, Joshua T. Mattila
The paper profiles macrophage diversity in TB granulomas using single-cell RNA sequencing and immunofluorescence in nonhuman primates, identifying distinct subsets and their roles in Mtb infection.
bioRxiv · Jun 12, 2025 · PreprintImmunology