David G. Russell

This study identifies the GID/CTLH complex as a regulator of metabolism and innate immunity in macrophages infected with Mycobacterium tuberculosis through ubiquitylation profiling and functional analysis.

This study identifies novel compounds that inhibit HIV-1 replication in primary human macrophages by targeting epigenetic regulators.

This paper develops a 96-well plate assay to identify anti-TB drugs effective against drug-tolerant Mtb in macrophages, showing host immune stresses can induce tolerance or synergize with certain drugs.

The paper profiles macrophage diversity in TB granulomas using single-cell RNA sequencing and immunofluorescence in nonhuman primates, identifying distinct subsets and their roles in Mtb infection.

This study shows that impaired macrophage fatty acid metabolism limits Mycobacterium tuberculosis growth through multiple anti-microbial mechanisms.

The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.

This study explores using USP18 inhibition to achieve anti-HIV activity through molecular simulations, free-energy profiling, and multi-cellular assays, showing reversible non-competitive inhibition and potential for antiviral strategies.