Author

Cal Gunnarsson

Ragon Institute of MGH, MIT and Harvard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Bryan D. BrysoniD· 4 shared Jacob B. Hochfelder· 2 shared Alex K. ShalekiD· 1 shared Beth A. Fallert Junecko· 1 shared Bianca A. Lepe· 1 shared Chiara Martello· 1 shared David Ren· 1 shared Douaa MugahidiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersImmunology

Bryan D. BrysonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I

Owen K. Leddy, Cal Gunnarsson, Patrick V. Holec, David Ren, Chiara Martello, Michael E. Birnbaum, Forest M. White, Bryan D. Bryson

The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.

bioRxiv · Oct 22, 2026 · PreprintImmunology

Bacterial surface display enables lysis-independent joint host-pathogen single-cell profiling

Cal Gunnarsson, Jeff C. Hsiao, Jacob B. Hochfelder, Sydney L. Solomon, Bianca A. Lepe, Sharon Zhu, Kelly Xu, Hattie Chung, Bryan D. Bryson

This paper introduces a lysis-independent method for joint host-pathogen single-cell profiling using bacterial surface display, enabling analysis of both host and pathogen features in infected cells.

bioRxiv · Jul 22, 2026 · PreprintBioengineering

Systems-level characterization of EGFR kinase inhibitors reveals heterogeneous effects on Mtb-macrophage interactions

Cal Gunnarsson, Rachel A. McGinn, Jacob B. Hochfelder, Bryan D. Bryson

This study examines the effects of EGFR kinase inhibitors on Mtb-macrophage interactions, finding heterogeneous outcomes and both direct and host-dependent mechanisms of action.

bioRxiv · Oct 17, 2025 · PreprintSystems Biology

Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity

Joshua M. Peters, Hannah Priyadarshini Gideon, Travis K. Hughes, Cal Gunnarsson, Pauline A Maiello, Douaa Mugahid, Sarah K. Nyquist, Joshua D. Bromley, Paul C. Blainey, Beth A. Fallert Junecko, Molly L. Nelson, Douglas A. Lauffenburger, Philana Ling Lin, JoAnne L. Flynn, Alex K. Shalek, , Bryan D. Bryson

This study uses multi-omics approaches to analyze myeloid cell diversity in TB granulomas and identifies IFN-γ, TGF-β, and time as factors driving macrophage diversity.

bioRxiv · May 24, 2024 · PreprintImmunology