Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)
Sung-Ung Kang, Jinhee Park, Shinwon Ha, Dongsan Kim, Olga Pletniková, Javier Redding‐Ochoa, Juan Carlos Troncoso, Quan Peng, Beth O. Van Emburgh, Jaldhir Trivedi, Saurav Brahmachari, Bardia Nezami, Valina Lynn Dawson, Ted M. Dawson
This study uses HiF-snRNA-seq to analyze the cingulate cortex in Parkinson's disease and Parkinson's disease dementia, identifying cell-type-specific gene expression changes and disease-stage-related pathways.
bioRxiv · Mar 1, 2025 · PreprintGenomics