Author

Saurav Brahmachari

Johns Hopkins UniversityORCID 0009-0004-3056-6213Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:Drosophila· 1

Frequent Co-Authors

Ted M. DawsoniD· 4 shared Valina Lynn DawsoniD· 4 shared Donghoon KimiD· 2 shared Han Seok KoiD· 2 shared Hao Gu· 2 shared Javier Redding‐OchoaiD· 2 shared Juan Carlos TroncosoiD· 2 shared Sangjune KimiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersNeuroscience

Ted M. DawsonORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 1, 2025

Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)

Sung-Ung Kang, Jinhee Park, Shinwon Ha…·Ted M. Dawson

This study uses HiF-snRNA-seq to analyze the cingulate cortex in Parkinson's disease and Parkinson's disease dementia, identifying cell-type-specific gene expression changes and disease-stage-related pathways.

1 citation

humansnRNA-seq

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NeurosciencebioRxivPreprintOct 3, 2022

Enhanced mTORC1 signaling and Protein Synthesis in Parkinson Disease Pathogenesis

Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang…·Ted M. Dawson

This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.

DOI 10.1101/2022.10.03.510455

mouseDrosophila

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NeuroscienceJournal of Proteome ResearchPeer-reviewedJun 1, 2021

Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in alpha-synuclein-based mouse models of Parkinson's disease

Shi-Xun Ma, Bo Am Seo, Donghoon Kim…·Han Seok Ko

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

59 citationstop 4%

mouseproteomics

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NeurosciencebioRxivPreprintMay 1, 2021

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

Xiaobo Mao, Hao Gu, Donghoon Kim…·Ted M. Dawson

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.

15 citations

mouseexperimental assay

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