Author

Javier Redding‐Ochoa

Johns Hopkins UniversityORCID 0000-0002-0677-917XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 5 Approach:statistical model· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell-cell communication· 3

Frequent Co-Authors

Juan Carlos TroncosoiD· 8 shared Ted M. DawsoniD· 4 shared Valina Lynn DawsoniD· 4 shared Olga PletnikováiD· 3 shared Cristian A. Lasagna‐ReevesiD· 2 shared David Aaron RoutenbergiD· 2 shared Evan Alexander Gizzie· 2 shared Hu WangiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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8 shared papersNeuroscience

Juan Carlos TroncosoORCID

Mutual co-authors in cluster

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8 papers

Recent·Most cited

Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer's disease across model systems.

Pablo Martínez, Henika Patel, Yanwen You, Daniella Lopes, Armando Amaro, Nur Jury, Yuhao Min, Javier Redding‐Ochoa, Sayan Dutta, Jean‐Christophe Rochet, Nilüfer Ertekin‐Taner, Juan Carlos Troncoso, Cristian A. Lasagna‐Reeves

The paper identifies distinct protein interactors of Tau-seed in AD across species and brain regions, highlighting functional differences in Tau propagation.

bioRxiv · Jun 17, 2025 · PreprintNeuroscience

Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)

Sung-Ung Kang, Jinhee Park, Shinwon Ha, Dongsan Kim, Olga Pletniková, Javier Redding‐Ochoa, Juan Carlos Troncoso, Quan Peng, Beth O. Van Emburgh, Jaldhir Trivedi, Saurav Brahmachari, Bardia Nezami, Valina Lynn Dawson, Ted M. Dawson

This study uses HiF-snRNA-seq to analyze the cingulate cortex in Parkinson's disease and Parkinson's disease dementia, identifying cell-type-specific gene expression changes and disease-stage-related pathways.

bioRxiv · Mar 1, 2025 · PreprintGenomics

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson's Disease

Bo Am Seo, Seung‐Hwan Kwon, Donghoon Kim, Han-Byeol Kim, Shixun Ma, Kundlik Gadhave, Noelle Burgess, Xiaobo Mao, Liana S. Rosenthal, Javier Redding‐Ochoa, Juan Carlos Troncoso, Seulki Lee, Valina Lynn Dawson, Ted M. Dawson, Han Seok Ko

This paper identifies NOD2/RIPK2 signaling as a key driver of neuroinflammation in Parkinson's disease, showing that pathological α-synuclein activates this pathway in microglia, leading to neurodegeneration and that targeting NOD2 or RIPK2 protects dopamine neurons.

bioRxiv · Feb 19, 2024 · PreprintNeuroscience

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam A. Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, , Xiaobo Mao

This study identifies Lag3 as a neuronal receptor for Tau preformed fibrils, essential for their uptake, propagation, and transmission in Tauopathies.

Advanced Science · Feb 7, 2024Peer-reviewedNeuroscience

Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer 's disease

Nur Jury, Yanwen You, Pablo Martínez, Javier Redding‐Ochoa, Hande Karahan, Travis S. Johnson, Jie Zhang, Jungsu Kim, Juan Carlos Troncoso, Cristian A. Lasagna‐Reeves

This study examines postmortem brains of AsymAD cases to identify mechanisms of cognitive resilience, finding enhanced microglial dynamics and reduced tau seeding in the amyloid plaque microenvironment.

bioRxiv · Jul 27, 2023 · PreprintNeuroscience

Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles

Yiyao Huang, Tanina Arab, Ashley E. Russell, Emily R. Mallick, Rajini Nagaraj, Evan Alexander Gizzie, Javier Redding‐Ochoa, Juan Carlos Troncoso, Olga Pletniková, Andrey A. Turchinovich, David Aaron Routenberg, Kenneth Whitaker Witwer

The paper characterizes extracellular vesicles (EVs) from different brain regions, revealing regional differences in EV yield, surface markers, and RNA content.

bioRxiv · May 6, 2023 · PreprintNeuroscience

Surface phenotyping and quantitative proteomics reveal differentially enriched proteins of brain-derived extracellular vesicles in Parkinson's disease

Tanina Arab, Yiyao Huang, Rajini Nagaraj, Evan Alexander Gizzie, Javier Redding‐Ochoa, Juan Carlos Troncoso, Olga Pletniková, Tatiana N. Boronina, Robert Norman Cole, Vasiliki Mahairaki, David Aaron Routenberg, Kenneth Whitaker Witwer

The paper identifies differentially enriched proteins in brain-derived extracellular vesicles from Parkinson's disease, PSP, and control samples using surface phenotyping and proteomics.

bioRxiv · Oct 17, 2022 · PreprintNeuroscience

Enhanced mTORC1 signaling and Protein Synthesis in Parkinson Disease Pathogenesis

Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang, Jaba Mitra, Hu Wang, Saurav Brahmachari, Senthilkumar S. Karuppagounder, Yasuyoshi Kimura, Aanishaa Jhaldiyal, Hyun Hee Kim, Hao Gu, Rong Chen, Javier Redding‐Ochoa, Juan Carlos Troncoso, Taekjip Ha, , Ted M. Dawson

This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.

bioRxiv · Oct 3, 2022 · PreprintNeuroscience