Sung-Ung Kang

The paper identifies circadian-organized non-covalent PAR-binding E3 ligases in the brain, linking PAR signaling to time-dependent ubiquitin control and disease-relevant biology.

This study identifies microglial Lag3 as a key receptor linking extracellular α-synuclein PFF recognition to neurotoxic astrocyte conversion and dopaminergic neurodegeneration.

This study shows that PARIS in neurons activates STAT3, leading to tau pathology and glial activation in Alzheimer's disease, and identifies the PARIS-STAT3 pathway as a therapeutic target.

This study uses HiF-snRNA-seq to analyze the cingulate cortex in Parkinson's disease and Parkinson's disease dementia, identifying cell-type-specific gene expression changes and disease-stage-related pathways.

This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.

The paper identifies ACE2-expressing endothelial and mural cells in mouse brains and links their functional changes to age-related vulnerability to viral infection.