GOLIATH regulates LDLR availability and plasma LDL cholesterol levels
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Michael Seldin, Pauline Morand, Richard E. Lee Jr., Ángel Baldán, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
This study identifies GOLIATH as an E3 ubiquitin ligase that regulates LDLR availability and plasma LDL cholesterol levels by ubiquitinating LDLR and redistributing it away from the plasma membrane.
bioRxiv · Dec 9, 2020 · PreprintMolecular Biology