Marcus Michael Seldin

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.

This study measures cardiac metabolite exchange in pigs during myocardial ischemia and reperfusion, revealing dynamic metabolic changes and transient protein degradation.

Correlation-based endocrine network analysis of MoTrPAC rat multi-tissue omics shows 8-week endurance training reshapes inter-organ secretory crosstalk, centering subcutaneous adipose, extracellular matrix factors, and Wnt regulators.

The paper identifies T cells and TNF-β as associated with PMOS-like phenotypes and shows T cells are necessary for letrozole-induced LH elevation in a mouse model.

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

This study identifies TNSST neurons in mice that modulate feeding behavior based on metabolic and reproductive states, with effects dependent on body mass and estrogen levels.

The paper identifies three genetic loci influencing mitochondrial proteins and heart hypertrophy in mice using proteomics and association mapping.

The paper identifies UFMylation as a negative regulator of skeletal muscle function through proteome-wide systems genetics in mice and validates it in a disease model.

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.

CoffeeProt is an open-source tool that integrates proteomics, genetics, and phenotypic data to identify functionally relevant genetic associations in mouse and human populations.

This study identifies GOLIATH as an E3 ubiquitin ligase that regulates LDLR availability and plasma LDL cholesterol levels by ubiquitinating LDLR and redistributing it away from the plasma membrane.

The paper identifies DNA methylation associations with metabolic syndrome traits in adipose tissue and develops a biomarker for type II diabetes risk.