This study shows Mycobacterium tuberculosis remodels its lipidome to survive phosphate starvation by using phosphorus-free lipids and host-derived phosphate sources.

Nature Communications · Nov 20, 2025Peer-reviewedMicrobiology

Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis

Nathan Peroutka‐Bigus, Michael S. Sherman, Firat Kaya, Samanthi L. Waidyarachchi, Jiuyu Liu, Joel N. Rushefsky, Michelle M. Butler, Terry L. Bowlin, Bernd Meibohm, Mercedes Gonzalez Juarrero, Anne J. M. Lenaerts, Matthew Zimmerman, Richard E. Lee Jr., Gregory T. Robertson

This study evaluates replacing linezolid with spectinamide MBX-4888A in the Nix-TB regimen for tuberculosis in a mouse model, showing potential for reduced adverse effects.

Antimicrobial Agents and Chemotherapy · Sep 30, 2025Peer-reviewedMicrobiology

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

Yi Miao, Vikas Yadav, William R. Shadrick, Jiuyu Liu, Alexander R. Jenner, Connie B. Nichols, Clifford T. Gee, Martin Schäfer, Jennifer L. Tenor, John R. Perfect, Richard E. Lee Jr., Richard G. Brennan, E. Washington

This paper identifies 4456dh, a small molecule inhibitor of trehalose-6-phosphate synthase, which disrupts fungal thermal tolerance and virulence.

mBio · Aug 25, 2025Peer-reviewedMicrobiology

Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis

Allison A. Bauman, Jansy Passiflora Sarathy, Firat Kaya, Lisa M. Massoudi, Michael S. Scherman, Courtney Hastings, Jiuyu Liu, Min Xie, Elizabeth J. Brooks, Michelle E. Ramey, Isabelle L. Jones, Noalani D. Benedict, Madelyn R. Maclaughlin, Jake A. Miller-Dawson, Samanthi L. Waidyarachchi, , Gregory T. Robertson

This study shows that MBX-4888A, a spectinamide, shortens tuberculosis treatment in murine models by improving tissue distribution and working well with rifampin and pyrazinamide.

Antimicrobial Agents and Chemotherapy · Sep 30, 2024Peer-reviewedMicrobiology

Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease

David S. Kim, Brandee M. S. S. Goo, Hong Shi, Philip Coffey, Praneet Veerapaneni, Ronnie Chouhaita, Nicole Cyriac, Ghaith Aboud, Stephen Cave, Jacob Greenway, Rohan Mundkur, Samah Ahmadieh, Ragheb Harb, Mourad Ogbi, David J. Fulton, , Neal L Weintraub

The paper analyzes multi-omics data from human saphenous veins to identify molecular and cellular changes during neointima proliferation, highlighting sex and BMI-related differences.

bioRxiv · Nov 14, 2023 · PreprintGenomics

GOLIATH regulates LDLR availability and plasma LDL cholesterol levels

Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Michael Seldin, Pauline Morand, Richard E. Lee Jr., Ángel Baldán, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling

This study identifies GOLIATH as an E3 ubiquitin ligase that regulates LDLR availability and plasma LDL cholesterol levels by ubiquitinating LDLR and redistributing it away from the plasma membrane.

bioRxiv · Dec 9, 2020 · PreprintMolecular Biology

Multi-level analysis of reproduction in an Antarctic midge identifies female and male accessory gland products that are altered by larval stress and impact progeny viability

Geoffrey Finch, Sonya Nandyal, Carlie Perretta, Benjamin Davies, Andrew J. Rosendale, Christopher J. Holmes, J. D. Gantz, Drew E. Spacht, Samuel T. Bailey, Xiaoting Chen, Kennan Oyen, Elise M. Didion, Souvik Chakraborty, Richard E. Lee Jr., David L. Denlinger, , Joshua B. Benoit

Scientific Reports · Nov 13, 2020Peer-reviewedGenomics