Targeting processive transcription for Myc-driven circuitry in medulloblastoma
Lays Martin Sobral, Faye M. Walker, Krishna P.C. Madhavan, Elizabeth Janko, Sahiti Donthula, Etienne P. Danis, Pradeep Bompada, Ilango Balakrishnan, Dong Wang, Angela M. Pierce, Mary M. Haag, Billie J. Carstens, Natalie Julie Serkova, Nicholas K. Foreman, Sujatha Venkataraman, , Nathan A. Dahl
This study identifies CDK9 as a conserved dependency in Myc-driven medulloblastoma and shows that CDK9 inhibition disrupts Myc-driven transcriptional programs, leading to anti-tumor effects.
Neuro-Oncology · May 12, 2025Peer-reviewedCancer Biology