Angela M. Pierce

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

This study identifies CDK9 as a conserved dependency in Myc-driven medulloblastoma and shows that CDK9 inhibition disrupts Myc-driven transcriptional programs, leading to anti-tumor effects.