Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity
Joaquín Pérez‐Schindler, Elyzabeth Vargas‐Fernández, Bettina Karrer‐Cardel…·Christoph Handschin
This study identifies transcription factor networks involved in hepatocyte lipotoxicity using integrative transcriptomic, proteomic, and chromatin accessibility analyses, showing that MAFK and TCF4 deletion protects against fatty acid toxicity.