Christoph Handschin

This study investigates how exercise induces molecular and signaling changes in the spinal cord using multi-omic approaches, revealing coordinated neuron-glia communication as key to spinal cord adaptation.

This study uses single-nucleus RNA-sequencing to analyze muscle adaptation in trained and untrained mice, showing divergent cellular responses and improved recovery with prior training.

This study shows that reduced RyR1 in muscle spindles of mice with recessive Ryr1 mutations causes proprioception issues and scoliosis.

This study identifies transcription factor networks involved in hepatocyte lipotoxicity using integrative transcriptomic, proteomic, and chromatin accessibility analyses, showing that MAFK and TCF4 deletion protects against fatty acid toxicity.

This study reveals that RNA-bound PGC-1α forms liquid-like nuclear condensates to regulate gene expression and transcriptional networks in response to metabolic stimuli.