Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope
Janine Hochmair, Christian Exner, Maximilian Franck, Alvaro Dominguez‐Baquero, Lisa Diez, Hevila Brognaro, Matthew L. Kraushar, Thorsten Mielke, Helena Radbruch, Senthilvelrajan Kaniyappan, Sven Falke, Eckhard Mandelkow�, Betzel Christian, Susanne Wegmann
This study shows that Tau condensation, driven by molecular crowding and RNA coacervation, leads to pathological Tau accumulation at the nuclear envelope and affects nucleocytoplasmic transport.
bioRxiv · Jan 24, 2022 · PreprintMolecular Biology