Author

Eckhard Mandelkow�

Center of Advanced European Studies and ResearchORCID 0000-0003-4655-4829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Senthilvelrajan KaniyappaniD· 3 shared Eva‐Maria MandelkowiD· 2 shared Jacek BiernatiD· 2 shared Alvaro Dominguez‐Baquero· 1 shared Bettina WarscheidiD· 1 shared Betzel Christian· 1 shared Christian ExneriD· 1 shared Christoph KlattiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Senthilvelrajan KaniyappanORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 24, 2022

Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope

Janine Hochmair, Christian Exner, Maximilian Franck…·Susanne Wegmann

This study shows that Tau condensation, driven by molecular crowding and RNA coacervation, leads to pathological Tau accumulation at the nuclear envelope and affects nucleocytoplasmic transport.

3 citations

experimental assay

𝕏 PostBluesky

NeuroscienceJournal of Biological ChemistryPeer-reviewedOct 26, 2020

Combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Friedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan…·Eckhard Mandelkow�

54 citationstop 5%

humanproteomics

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NeuroscienceMolecular NeurodegenerationPeer-reviewedJul 16, 2020

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau fibers

Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat…·Eckhard Mandelkow�

This paper shows that FRET-based Tau seeding assays do not reflect prion-like templated assembly of Tau fibers, as GFP tags inhibit aggregation and alter fiber structure.

64 citationstop 3%

protein structureexperimental assay

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