Matthew L. Kraushar

Recording proteome dynamics in the late-stage embryo at hour-timescale, spatial, and single-cell resolution with MEMBRYO

The paper introduces MEMBRYO, a method for continuous SILAC proteomics in live embryos, revealing post-transcriptional regulation during neurogenesis.

Nucleolus transformation and Pol1 activity pattern dual transcriptomes of neuronal subtype identity

The paper identifies that nucleolar restructuring and Pol1 activity patterns are linked to neuronal subtype identity through dual rRNA-mRNA transcriptomes in developing neocortex.

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

Ribosomal RNA 2'-O-methylation dynamics impact cell fate decisions

The paper examines how changes in rRNA 2'-O-methylation during development and differentiation affect cell fate decisions in mouse and human cells.

A critical period of translational control during brain development at codon resolution

The paper measures translation dynamics in mouse neocortex neurogenesis, revealing a critical period of translational control that regulates protein expression and neuronal differentiation.

SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff

This study identifies the role of Nsp1's N-terminal and linker regions in host translational shutoff by mapping their interactions with ribosomal and eIF3 components.

Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope

This study shows that Tau condensation, driven by molecular crowding and RNA coacervation, leads to pathological Tau accumulation at the nuclear envelope and affects nucleocytoplasmic transport.

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit

The paper reveals Ebp1's role in neuronal proteostasis by analyzing ribosomal architecture and proteomic changes in the developing mouse neocortex.

Multiple roles of PIWIL1 in mouse neocorticogenesis

This study investigates the role of Piwil1 in mouse neocorticogenesis, finding it essential for cell cycle, neuron migration, and dendritogenesis, with effects independent of piRNA expression.