In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain
Tyson Joel Ruetz, Chloe M. Kashiwagi, Bhek Morton, Robin W. Yeo, Dena S. Leeman, David W. Morgens, C. Kimberly Tsui, Amy Li, Michael Cory Bassik, Anne Brunet
The paper uses CRISPR-Cas9 screens in vitro and in vivo to identify gene knockouts that enhance neural stem cell activation in aged mice, finding that GLUT4 knockout is a top rejuvenating intervention.
bioRxiv · Nov 23, 2021 · PreprintNeuroscience