Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem stem cell adhesion and migration during aging
Robin W. Yeo, Olivia Y. Zhou, Brian L. Zhong, Eric Sun, Paloma Navarro Negredo, Surag Nair, Mahfuza Sharmin, Tyson Joel Ruetz, Mikaela Wilson, Anshul Bharat Kundaje, Alexander R. Dunn, Anne Brunet
The paper investigates chromatin accessibility changes in neurogenic niche cells during aging, identifying defects in NSC adhesion and migration and proposing ROCK inhibition as a potential therapeutic strategy.
Nature Aging · Jul 13, 2023Peer-reviewedNeuroscience