Compensatory tRNA Modification by DUS3L Confers Resistance to METTL1 Loss in Oesophageal Cancer
Helena Santos-Rosa, Jonathan L. Price, Georgia Tsagkogeorga, Alexandra Sapetschnig, Bianca Pierattini, David Jordan, Paula Milán-Rois, Almudena Serrano-Benítez, Katherine M. Stott, Namshik Han, Tony Kouzarides, Eric Alexander Miska
The paper identifies a compensatory tRNA modification pathway mediated by DUS3L that allows oesophageal cancer cells to resist METTL1 loss, suggesting DUS3L as a biomarker and therapeutic target.
bioRxiv · Oct 13, 2025 · PreprintBiochemistry