Tony Kouzarides

Compensatory tRNA Modification by DUS3L Confers Resistance to METTL1 Loss in Oesophageal Cancer

The paper identifies a compensatory tRNA modification pathway mediated by DUS3L that allows oesophageal cancer cells to resist METTL1 loss, suggesting DUS3L as a biomarker and therapeutic target.

METTL9 sustains vertebrate neural development primarily via non-catalytic functions

The paper investigates METTL9's role in vertebrate neural development, finding its non-catalytic functions sustain neurogenesis through secretory pathway modulation.

PhOxi-seq detects enzyme-dependent m2G in multiple RNA types

The paper introduces an optimized PhOxi-seq workflow and bioinformatic pipeline to detect enzyme-dependent m2G modifications across multiple RNA types, generating a database of high-confidence THUMPD3-dependent m2G sites in human cancer cells.

Pseudouridine guides germline small RNA transport and epigenetic inheritance

The paper identifies pseudouridine as a marker for germline small RNAs in plants and mammals, showing its role in epigenetic inheritance through nuclear transport.

Predicting genes associated with RNA methylation pathways using machine learning

This study uses machine learning to predict genes associated with RNA methylation pathways in humans using multi-omics data from the Harmonizome database.

RNA modifications detection by comparative Nanopore direct RNA sequencing

The paper introduces Nanocompore, a method to detect RNA modifications using Nanopore direct RNA sequencing, validated on human polyA+ RNAs and non-coding RNAs.

A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry

The paper introduces NASE, a database search engine for RNA mass spectrometry data, demonstrating its ability to identify modified RNA sequences in three datasets.

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

The paper identifies RNA binding proteins and RNAs interacting with Sox2 in mouse embryonic stem cells, showing coexistence in a ribonucleoprotein complex without evidence of chromatin recruitment regulation.

Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci

The paper identifies positionally conserved lncRNAs linked to developmental loci and chromatin organization, revealing their functional connections to coding genes and cancer metastasis.