Shape-Shifting Conotoxins Reveal Divergent Pore-Targeting Mechanisms in Nicotinic Receptors
Biddut Bhattacharjee, Colleen Noviello, Md Mahfuzur Rahman, John P. Mayer, Joanna Gajewiak, J. Michael McIntosh, Ryan E. Hibbs, Michael H. B. Stowell
This study uses cryoEM to reveal how two conotoxins bind differently to nicotinic acetylcholine receptors, showing distinct structural and functional mechanisms despite similar sequences.
Structure · Dec 29, 2025Peer-reviewedNeuroscience