Michael H. B. Stowell

This paper develops a cryoprotectant-assisted plunge freezing method for preserving thick mouse brain tissue for cryo-imaging, enabling high-resolution visualization of cellular structures and validating their physiological relevance.

This study shows that TDP-43 is essential for building and maintaining sarcomeres, as its absence leads to muscle atrophy and disrupted sarcomere organization.

This study identifies Synaptotagmin-2 and Synaptotagmin-3 as distinct calcium sensors for glutamatergic and GABAergic release in lateral habenula neurons.

This study uses cryoEM to reveal how two conotoxins bind differently to nicotinic acetylcholine receptors, showing distinct structural and functional mechanisms despite similar sequences.

The paper identifies a novel mechanism of serum-induced hyperalgesia through the facilitation of Cav3.2 channel gating by the peptide albumin (1-26).

The paper introduces a deep learning method for ligand identification in cryoEM and X-ray density maps, showing it performs as well as existing methods for X-ray data and can be applied to cryoEM data.

This study investigates how AD-specific post-translational modifications affect Tau self-assembly into PHFs, finding that phosphorylation generally inhibits aggregation while acetylation has variable effects.

This study shows CBD disrupts cholesterol homeostasis in human cell lines, altering metabolites, transcripts, and proteins related to cholesterol biosynthesis, transport, and storage.

The paper identifies a contaminant peptide in synthetic Amyloid-β42 that inhibits cytotoxicity and fibrillation.

The paper uses proteomics to identify early changes in AD model mice synaptosomes, finding significant proteomic alterations before traditional disease markers appear.

This study shows that Aβ42 binds to synaptophysin, disrupting its function and leading to impaired neurotransmission and increased seizure susceptibility in an Alzheimer’s model.