J. Michael McIntosh

This study uses cryoEM to reveal how two conotoxins bind differently to nicotinic acetylcholine receptors, showing distinct structural and functional mechanisms despite similar sequences.

The paper uses structural bioinformatics to identify a new conotoxin family with a two-finger toxin fold, revealing evolutionary relationships among rapidly evolving genes.

The paper identifies molleamine C as a partial antagonist of nicotinic acetylcholine receptors with potential for neuroactive drug development.

The paper shows that full activation of an α7-α3β4 nicotinic receptor complex in human chromaffin cells reduces desensitization, while choline limits current increases, and this interaction weakens with age.

This study investigates efferent synaptic inputs to type II vestibular hair cells using optogenetic and electrical stimulation, revealing hyperpolarization and facilitation during repetitive stimulation.

This study demonstrates that acetylcholine (ACh) signaling at retinal synapses exhibits both synaptic and non-synaptic transmission characteristics, with rapid currents and limited spread.

This study shows that VTA glutamate neurons express nicotinic acetylcholine receptors and are modulated by cholinergic input, affecting excitatory transmission.