MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony
Gangadhar Eluru, Steven De Gieter, Stephan Schenck, Annelore Stroobants, Binesh Shrestha, Paul J. A. Erbel, Janine Denise Brunner, Rouslan G. Efremov
The paper introduces MISO, a method combining microfluidics and cryo-EM to determine protein structures from single cell colonies with high sensitivity.
Nature Methods · Nov 13, 2025Peer-reviewedBiophysics