Janine Denise Brunner

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony

The paper introduces MISO, a method combining microfluidics and cryo-EM to determine protein structures from single cell colonies with high sensitivity.

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

This study determines the structures of native SV2A, revealing its binding modes for tetanus neurotoxin and anti-epileptic drugs, and provides insights into toxin-receptor interactions and drug specificity.

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

A biosensor-based phage display selection method for automated, high-throughput Nanobody discovery

This paper introduces a biosensor-based phage display method for high-throughput Nanobody discovery, reducing time and labor by using automated Octet biolayer interferometry.