A Standalone PD-1 Chimeric Switch Receptor T-Cell Platform Expands the Therapeutic Window of PD-L1 Targeting in Solid Tumors
Yan Luo, Shaohua Guo, Yaqing Qie, Binyan Zhao, Maria Jose Ulloa-Navas, Mieu Brooks, Vanessa Jones, Tanya Hundal, Julio C Chavez, Yanyan Lou, Loic Pierre Deleyrolle, Vamsidhar Velcheti, James W Jakub, Roxana Dronca, Mohamed A Kharfan-Dabaja, , Hong Qin
This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.
bioRxiv · Nov 9, 2026 · PreprintMolecular Biology