Recruiting ESCRT to single-chain heterotrimer peptide-MHCI releases antigen-presenting vesicles that stimulate T cells selectively
Blade A. Olson, Kathryn E. Huey‐Tubman, Zhiyuan Mao, Magnus A. G. Hoffmann, Pamela J. Björkman, Richard M. Murray, Stephen L. Mayo
This study demonstrates a method to generate antigen-presenting vesicles displaying pMHCI using engineered constructs, which selectively stimulate T cells for potential cell-free immunotherapy.
Proceedings of the National Academy of Sciences · Dec 15, 2025Peer-reviewedImmunology