Oncogenic KRAS regulates secretion of extracellular vesicles and surface membrane charge via regulation of phosphatidylserine in pancreatic cancer
Kshipra S. Kapoor, Xin Luo, Kaira A. Church, Martin M Bell, Bo Fan, Seoyun Kong, Elena V. Ramirez, Yilin Chen, Fernanda Grande Kugeratski, Sibani Lisa Biswal, Kathleen M. McAndrews, Florian Gebauer, Christoph Kahlert, Jacob T. Robinson, Raghu Kalluri
This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.
bioRxiv · Sep 21, 2025 · PreprintBioengineering