The paper identifies novel probiotic bacteria associated with IgA responses against enteric pathogens in infants, suggesting their potential use in improving infant formula.

bioRxiv · Oct 27, 2025 · PreprintMicrobiology

Oncogenic KRAS regulates secretion of extracellular vesicles and surface membrane charge via regulation of phosphatidylserine in pancreatic cancer

Kshipra S. Kapoor, Xin Luo, Kaira A. Church, Martin M Bell, Bo Fan, Seoyun Kong, Elena V. Ramirez, Yilin Chen, Fernanda Grande Kugeratski, Sibani Lisa Biswal, Kathleen M. McAndrews, Florian Gebauer, Christoph Kahlert, Jacob T. Robinson, Raghu Kalluri

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

bioRxiv · Sep 21, 2025 · PreprintBioengineering

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

Xin Luo, Kathleen M. McAndrews, Kent A. Arian, Sami J. Morse, Viktoria Boeker, Shreyasee V. Kumbhar, Yingying Hu, Krishnan K. Mahadevan, Kaira A. Church, Sriram Chitta, Nicolas T. Ryujin, Janine Hensel, Jianli Dai, Dara P. Dowlatshahi, Hikaru Sugimoto, , Raghu Kalluri

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

Journal of Controlled Release · Aug 30, 2024Peer-reviewedImmunology