Raghu Kalluri

TGF-β2-induced Snail-mediated EndMT signaling relies on both Smad-dependent and independent pathways

The paper reproduces and validates a previously reported model of TGF-β2-induced EndMT through Smad-dependent and independent pathways across multiple studies and laboratories.

Engineered extracellular vesicles targeting BACE1 reduces amyloid beta plaque formation in a genetic mouse model of Alzheimer Disease

This study shows engineered extracellular vesicles delivering BACE1-targeting siRNA reduce amyloid beta plaques in a mouse model of Alzheimer's disease.

VrySure: A Multi-Task AI Scientific Fraud Detection Platform for Identifying Manipulated and AI-Generated Biomedical Research Images

VrySure is an AI platform that detects manipulated and AI-generated biomedical images using multiple modules, achieving higher accuracy in some tasks compared to existing tools.

Differential Akt Signaling Induced by Tumstatin and Endostatin in Human Endothelial Cells

This study compares Akt signaling induced by Tumstatin and Endostatin in human endothelial cells, finding Tumstatin reduces Akt phosphorylation while Endostatin does not affect Akt activation.

Oncogenic KRAS regulates secretion of extracellular vesicles and surface membrane charge via regulation of phosphatidylserine in pancreatic cancer

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer

This study identifies small molecule Kras inhibitors that synergize with anti-CTLA4 therapy to reprogram Tregs and enhance immunotherapy efficacy in PDAC.

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

This paper develops a machine learning method to identify cancer exosomes using a proteomic signature, achieving high accuracy across multiple biological fluids.

Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.

Multiple antibodies identify glypican-1 associated with exosomes from pancreatic cancer cells and serum from patients with pancreatic cancer

The paper confirms Glypican-1 enrichment on pancreatic cancer exosomes using multiple antibodies and demonstrates specific detection in patient serum.