Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic Plaques
Pengbo Hou, Huan Cai, Zhanhong Liu, Jiankai Fang, Ziyi Wang, Shiqing Wang, Qingkang Lyu, Peishan Li, Changshun Shao, Gerry Melino, Klaus F. Ley, Bo Hu, Yufang Shi
This study uses spatial multi-omics to identify myeloid cell subsets and their functional roles in human atherosclerotic plaques, linking ECM and lipid cues to macrophage state transitions.
bioRxiv · Oct 9, 2025 · PreprintPathology