Bo Hu

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

This study investigates the epigenetic and transcriptomic effects of NSD1 mutations in head and neck squamous cell carcinoma, showing loss of H3K36me2 and DNA methylation, and gain of H3K27me3, leading to gene expression changes.