Klaus F. Ley

This study identifies Treg destabilization as a staged differentiation process in atherosclerosis, leading to diverse exTreg states driven by IL-6R signaling.

This study uses EGFP-talin1 knock-in mice to show talin-1 dynamics during neutrophil migration in vivo, revealing its polarization during directional movement.

scDIG is an R Shiny tool for interactive density-based gating of single-cell proteomic and transcriptomic data, resolving CD4+ T cell subpopulations in CITE-seq data.

This study identifies molecular changes in perivascular adipose tissue in lupus mice, showing mitochondrial dysfunction, immune activation, and impaired adipogenic capacity.

This study uses spatial multi-omics to identify myeloid cell subsets and their functional roles in human atherosclerotic plaques, linking ECM and lipid cues to macrophage state transitions.

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

This study identifies an IL-2 mutant that disrupts alternative signaling by blocking CD25-CCR7 complex formation while preserving canonical signaling.

This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.

PRESTO integrates large-scale -omics data and identifies disease-specific gene signatures through unsupervised dimensionality reduction and visualization.