Hyperexcitability precedes CA3 hippocampal neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.
William Rodemer, Irene Ra, Elizabeth Jia, Jaskeerat Gujral, Bin Zhang, Kevt’her Hoxha, Bo Xing, Sanya Mehta, Madona Farag, Sílvia Porta, Frances E. Jensen, Delia M. Talos, Virginia M.‐Y. Lee
This study shows that hyperexcitability precedes neurodegeneration in a TDP-43 mouse model of ALS-FTD, but targeting hyperexcitability does not prevent neuron loss.
bioRxiv · Sep 24, 2024 · PreprintNeuroscience