Author

Sílvia Porta

University of PennsylvaniaORCID 0000-0003-3667-4325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Virginia M.‐Y. LeeiD· 2 shared Alice S. Chen‐PlotkiniD· 1 shared Bin ZhangiD· 1 shared Bo Xing· 1 shared David A. WolkiD· 1 shared Defne A. AmadoiD· 1 shared Delia M. TalosiD· 1 shared Edward B. LeeiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Virginia M.‐Y. LeeORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 24, 2024

Hyperexcitability precedes CA3 hippocampal neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.

William Rodemer, Irene Ra, Elizabeth Jia…·Virginia M.‐Y. Lee

This study shows that hyperexcitability precedes neurodegeneration in a TDP-43 mouse model of ALS-FTD, but targeting hyperexcitability does not prevent neuron loss.

1 citation

mouseexperimental assay

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NeuroscienceActa NeuropathologicaPeer-reviewedJun 21, 2021

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

Fei Mao, John L. Robinson, Travis L. Unger…·Alice S. Chen‐Plotkin

This study investigates how TMEM106B and C9orf72 genetic variants influence TDP-43 pathology in ALS and FTLD-TDP, finding TMEM106B modifies TDP-43 aggregation severity.

28 citations

humanproteomics

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