Delia M. Talos

This study examines temporal and cell-specific changes in iron sequestration and lipid peroxidation in a murine model of neonatal hypoxic-ischemic brain injury, finding acute iron and DHA peroxidation correlate with cell death peaks at 24h post-injury.

This study shows that seizures worsen tau pathology in a tauopathy mouse model by promoting tau propagation in seizure-activated neurons.

This study shows that neuronal hyperactivity and seizures increase tau spread in an Alzheimer's disease mouse model and correlate with memory deficits.

This study shows that hyperexcitability precedes neurodegeneration in a TDP-43 mouse model of ALS-FTD, but targeting hyperexcitability does not prevent neuron loss.

The paper investigates E:I imbalance in AD patients and 5XFAD mice, showing seizures worsen it and rapamycin treatment can reverse some effects.