Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates ageing in mice
Oleksandra Sirozh, Bomi Jung, Laura Sanchez‐Burgos, Iván Ventoso, Vanesa Lafarga, Óscar Fernández-Capetillo
This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.
bioRxiv · Aug 10, 2023 · PreprintMolecular Biology