Oleksandra Sirozh

This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.

The paper identifies chemical and genetic regulators of the tetracycline-inducible gene expression system in mammalian cells, showing that FDA-approved drugs and genetic modifiers inhibit the system rather than alleviate TDP-43 toxicity.

This study shows arginine-rich CPPs like (PR)n displace DNA- and RNA-binding factors, impairing nucleic acid processes and causing toxicity, similar to PROTAMINE's effects.