High-Speed AFM Reveals IDR-Mediated Structural Plasticity of EML4-ALK Modulated by ALK Inhibitors
Xujun Han, Noriyuki Kodera, Neval Yilmaz, Katsuya Sakai, Sachiko Arai, Borui Li, Ryu Imamura, Dominic Chih‐Cheng Voon, Koji Fukuda, Shigeki Nanjo, Holger Flechsig, Hiroyuki Mano, Kunio Matsumoto, Seiji Yano
The paper uses high-speed AFM to study how ALK inhibitors affect the structure and dynamics of EML4-ALK variants, revealing IDR-mediated plasticity and resistance mechanisms.
bioRxiv · Aug 7, 2025 · PreprintCancer Biology