Holger Flechsig

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

The paper introduces A3, a software platform for automated analysis of HS-AFM imaging data, enabling high-throughput quantitative analysis of biomolecular dynamics.

This study shows that coiled-coil kinking in laminin-332 directs elastase cleavage to a specific hinge site, ensuring proper fragment generation, while extended conformations lead to random cleavage and degradation.

The paper uses high-speed AFM to show that CaMKII/{beta} heterododecamers form stable structures with adjacent CaMKII{beta} subunits, revealing their structural role.

This study shows that myosin V can perform ATP-free walking by converting strain energy from actin binding into mechanical work, similar to ATP-dependent walking.

The paper introduces NMFF-AFM, a method to infer atomistic models of biomolecular dynamics from HS-AFM imaging data, and integrates it into BioAFMviewer for analysis and visualization.

The paper uses high-speed AFM to study how ALK inhibitors affect the structure and dynamics of EML4-ALK variants, revealing IDR-mediated plasticity and resistance mechanisms.

This study uses HS-AFM to visualize NTD dynamics of GluA2-γ2, showing dimer splitting and its role in synaptic clustering.

The paper uses high-speed atomic force microscopy to study activity-dependent structural dynamics of CaMKII in rat, hydra, and C. elegans, revealing species-specific structural changes and phosphatase tolerance in rat CaMKII.