Cancer BiologybioRxivPreprint
High-Speed AFM Reveals IDR-Mediated Structural Plasticity of EML4-ALK Modulated by ALK Inhibitors
Xujun Han, Noriyuki Kodera, Neval Yilmaz…·Seiji Yano
The paper uses high-speed AFM to study how ALK inhibitors affect the structure and dynamics of EML4-ALK variants, revealing IDR-mediated plasticity and resistance mechanisms.