Proteostasis as a fundamental principle of Tau immunotherapy
Esteban Cruz, Rebecca M. Nisbet, Pranesh Padmanabhan, Ashley J. Waardenberg, Mark Evan Graham, Godfrey Nkajja, Swara Tapaswi, Bradley J Connor, Phil Robinson, Jürgen Götz
This study shows that a novel Tau antibody, RNJ1, restores proteostasis in a tauopathy model by reducing pathological Tau and normalizing protein and phosphoprotein levels.
Brain · Jul 29, 2024Peer-reviewedNeuroscience