Ashley J. Waardenberg

DDHD2 provides a critical flux of saturated fatty acids to support neuronal energy demands

The paper shows that DDHD2-generated saturated fatty acids are essential for neuronal energy production and synaptic function.

Polyanionic peptibody ameliorates tau pathology and promotes neuronal proteostasis in a tau transgenic mouse model

This study develops a polyanionic peptibody, ACR12, that reduces tau aggregation and restores neuronal protein levels in a tau transgenic mouse model.

Proteostasis as a fundamental principle of Tau immunotherapy

This study shows that a novel Tau antibody, RNJ1, restores proteostasis in a tauopathy model by reducing pathological Tau and normalizing protein and phosphoprotein levels.

TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiation

This study identifies TWIST1 homodimers and heterodimers with E-proteins as key regulators of lineage-specific differentiation, revealing their distinct roles in mesoderm, neural crest, and endoderm development.

consensusDE: an R package for assessing consensus of multiple RNA-seq algorithms with RUV correction

consensusDE identifies consistent differential expression across RNA-seq algorithms while integrating RUV correction to improve stability.