Jürgen Götz

This study identifies Tau as a regulator of NMDA receptor trafficking during homeostatic synaptic plasticity, showing that Tau phosphorylation and interactions with Fyn kinase modulate receptor stability.

This study uses high-resolution imaging to compare the spatiotemporal biological responses of reversibly and irreversibly sonoporated cells, revealing distinct cellular bioeffects that determine their long-term fates.

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

This study shows that a novel Tau antibody, RNJ1, restores proteostasis in a tauopathy model by reducing pathological Tau and normalizing protein and phosphoprotein levels.

The paper shows that ultrasound treatment improves memory in AD mice without reducing amyloid-β, with higher frequency (1 MHz) being more effective than lower frequencies.

This study uses CRISPRi screening to identify cellular regulators that restrict both exosomal and vesicle-free tau seeding in Alzheimer's disease.

This study evaluates whether ultrasound-mediated delivery of a tau-specific monoclonal antibody improves therapeutic efficacy in a tauopathy model, finding increased brain uptake but no additive therapeutic benefit.

The paper analyzes the transcriptomic response of microglia in an Alzheimer's disease mouse model treated with scanning ultrasound, identifying differentially expressed genes and pathways related to phagocytosis and cell cycle activation.

This study identifies dynamic Tau hot spots near the plasma membrane that are stable against microtubule perturbations and cholesterol depletion.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.

This study compares the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in APP23 mice, finding that both reduce plaques and that the combination improves spatial memory.

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.