Pranesh Padmanabhan

This study identifies Tau as a regulator of NMDA receptor trafficking during homeostatic synaptic plasticity, showing that Tau phosphorylation and interactions with Fyn kinase modulate receptor stability.

This study uses high-resolution imaging to compare the spatiotemporal biological responses of reversibly and irreversibly sonoporated cells, revealing distinct cellular bioeffects that determine their long-term fates.

This study shows that a novel Tau antibody, RNJ1, restores proteostasis in a tauopathy model by reducing pathological Tau and normalizing protein and phosphoprotein levels.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

This study identifies dynamic Tau hot spots near the plasma membrane that are stable against microtubule perturbations and cholesterol depletion.

This study shows that actomyosin-II radial contractility regulates axonal cargo trafficking and structural stability by controlling transient radial expansion during cargo transport.