Esteban Cruz

Proteostasis as a fundamental principle of Tau immunotherapy

This study shows that a novel Tau antibody, RNJ1, restores proteostasis in a tauopathy model by reducing pathological Tau and normalizing protein and phosphoprotein levels.

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

This study evaluates whether ultrasound-mediated delivery of a tau-specific monoclonal antibody improves therapeutic efficacy in a tauopathy model, finding increased brain uptake but no additive therapeutic benefit.

Tau forms dynamic hot spots that are resistant to microtubule perturbations and cholesterol depletion

This study identifies dynamic Tau hot spots near the plasma membrane that are stable against microtubule perturbations and cholesterol depletion.

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.