Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches
Maximillian G. Marin, Natalia Quinones‐Olvera, Christoph Wippel, Mahboobeh Behruznia, Brendan M. Jeffrey, Michael Harris, Brendon Mann, Alex Rosenthal, Karen Rita Jacobson, Robin M. Warren, Heng Li, Conor Joseph Meehan, Maha Reda Farhat
The paper evaluates pan-genome analysis methods using M. tuberculosis isolates, finding that annotation discrepancies and assembly quality affect results, and introduces panqc to address these issues.
Bioinformatics · May 1, 2025Peer-reviewedBioinformatics