Mahboobeh Behruznia

Library preparation strategy critically impacts RNA virus sensitivity in clinical metagenomics

This study shows that library preparation methods significantly affect RNA virus detection in clinical metagenomics, with SISPA-based approaches outperforming others in most scenarios.

Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches

The paper evaluates pan-genome analysis methods using M. tuberculosis isolates, finding that annotation discrepancies and assembly quality affect results, and introduces panqc to address these issues.

pQEB1: a hospital outbreak plasmid lineage carrying blaKPC-2

The paper identifies a plasmid lineage pQEB1 carrying blaKPC-2 in a hospital outbreak, showing its multi-drug resistance and inter-patient transmission.

The Mycobacterium tuberculosis complex pangenome is small and shaped by sub-lineage-specific regions of difference

The paper quantifies the MTBC pangenome, revealing a small, closed genome with lineage-specific regions of difference and implications for virulence and drug resistance.

Borderline rpoB mutations transmit at the same rate as common rpoB mutations in a tuberculosis cohort in Bangladesh

The paper examines transmission rates of borderline and common rpoB mutations in MDR-TB isolates from Bangladesh, finding no difference in transmission clustering between mutation types.