Author

Karen Rita Jacobson

Boston UniversityORCID 0000-0003-4239-3685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:benchmarking· 2 Organism:human· 2 Research Focus:variant calling· 1

Frequent Co-Authors

Maha Reda FarhatiD· 3 shared Brendon C. ManniD· 2 shared Robin M. WarreniD· 2 shared Alex RosenthaliD· 1 shared Brendan M. JeffreyiD· 1 shared Brendon Mann· 1 shared C. Glanz· 1 shared Christoph WippeliD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

Maha Reda FarhatORCID

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3 papers

Recent·Most cited

MicrobiologyTuberculosisPeer-reviewedJan 29, 2026

Systematic review and meta-analysis of protocols and yield of direct from sputum sequencing of Mycobacterium tuberculosis

Brendon C. Mann, Johannes Loubser, Shatha Omar…·Maha R Farhat

This study identifies factors affecting the success of direct sputum whole genome sequencing for Mycobacterium tuberculosis, highlighting optimal pre-processing steps and the negative impact of sodium hydroxide decontamination.

5 citations

humanwhole-genome sequencing

BioinformaticsBioinformaticsPeer-reviewedMay 1, 2025

Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches

Maximillian G. Marin, Natalia Quinones‐Olvera, Christoph Wippel…·Maha Reda Farhat

The paper evaluates pan-genome analysis methods using M. tuberculosis isolates, finding that annotation discrepancies and assembly quality affect results, and introduces panqc to address these issues.

36 citationstop 1%

humanwhole-genome sequencing

Molecular BiologyJournal of Clinical MicrobiologyPeer-reviewedSep 20, 2023

Assessment and validation of enrichment and target capture approaches to improve Mycobacterium tuberculosis WGS from direct patient samples

Brendon C. Mann, Karen Rita Jacobson, Yonas T Ghebrekristos…·Maha Reda Farhat

The paper evaluates DNA decontamination methods and a new target enrichment protocol to improve Mycobacterium tuberculosis whole-genome sequencing from direct patient samples.

17 citations

whole-genome sequencingstatistical model